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   트위터  페이스북

 
 

 

· Name:              Hee-Sae Park, Ph.D

                         Professor

 

· E-mail:     proteome@jnu.ac.kr

 

 

· Education

  Mar.1998 – Aug. 2000:    Ph.D. in Graduate School ofBiotechnology (Biochemistry),

                                     Korea University

  Mar.1996 – Feb. 1998:    M.S. in Biochemistry (Biochemistry), Graduate School,

                                     Kyungpook National University

  Mar.1989 – Feb. 1996:    B.S. in Biochemistry, Yeungnam University

 

· Dissertation Title

  Ph.D. Thesis: Negative regulation of c-Jun N-terminal kinase signaling pathway.

  M.S. Thesis : Conformational changes of the leukocyteNADPH oxidase subunit p47

                    (phox) during activation studied through its intrinsicfluorescence.

 

· Fellowships

  1998 – 1999: Teaching Assistant, Korea University

  1999 – 2000: Research Assistant, Korea University

 

· Honors and Awards

  Aug, 2000: The best thesis awards, Korea University

  Jan, 2001: The best researcher awards, iNtron inc.

 

· Research Experiences

 April, 2012 - Present:


 Mar, 2007 –Mar, 2012:

 

Professor, School of Biological Sciences and  Technology, Chonnam National University

Associate Professor, School of Biological Sciences and  Technology, Chonnam National University

 Nov, 2003 – Feb, 2007:

 

Assistant Professor, School of Biological Sciences and Technology, Chonnam National University

 Feb, 2003 – Nov, 2003:

 

Assistant Professor, Department of Genetic Engineering, Chonnam NationalUniversity

 Mar, 2001 – Feb, 2003:

 

Research Associate, Department Molecular Biology and Pharmacology, Washington University in St. Louis

 Oct, 2000 – Feb, 2001:

 

Research Associate, National Creative Research Initiative (CRI) Centerfor Cell Death Graduate School of Biotechnology, Korea University

 Mar, 2000 – Sep, 2000:

 

Research Scientist, National Creative Research Initiative (CRI) Center for Cell Death Graduate School of Biotechnology, Korea University

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Selected Publication (above IF 5.0)

 

14. Notch1 modulates oxidative stress induced cell death through suppression of apoptosis signal-reulating kinase 1.

Jung-Soon Mo, Ji-Ae Yoon, Eun-Jung Ann, Ji-Seon Ahn, Hyeong-Jin Baek, Hye-Jin Lee, Seol-Hee Kim, Yeong-Dae Kim, Mi-Yeon Kim and Hee-Sae Park

PNAS, (2013) (IF: 9.85) In press

 

13. Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability.

Yun-Hee Choi, Eun-Jung Ann, Mi-Yeon Kim, Jung-Soon Mo and Hee-Sae Park

BBA-Mol Cell Res, 1883(1): 69-79 (2013) Jan (IF: 5.328) 

 

12.    Wnt5a controls Notch signaling through CaMKII mediated degradation of the SMRT corepressor protein.

Eun-Jung Ann*, Hwa-Young Kim*, Mi-Sun Seo*, Mi-Yeon Kim, Jung-Soon Mo, Ji-Seon Ahn, Ji-Hye Yoon and Hee-Sae Park

Journal of Biological Chemistry, 287 (44): 36812-36829 (2012) Oct (IF: 5.328)

 

11. Dual regulation of Notch1 signaling pathway by adaptor protein Fe65.

Mi-Yeon Kim, Jung-Soon Mo, Eun-Jung Ann and Hee-Sae Park

Journal of Biological Chemistry, (2011) (IF: 5.328)  In press

 

10. Presenilin 2 regulates the degradation of RBP-Jk protein via p38 mitogen-activated protein kinase: Degradation of RBP-Jk involves both proteasome and lysosome.

Su-Man Kim*, Mi-Yeon Kim*, Eun-Jung Ann, Jung-Soon Mo, Ji-Hye Yoon and Hee-Sae Park

Journal of Cell Science, (2011) (IF: 6.29) In press

 

9. Regulation of Notch1 signaling by APP intracellular domain facilitates the protein degradation of the Notch1 intracellular domain and RBP-Jk.

Mi-Yeon Kim*, Jung-Soon Mo*, Eun-Jung Ann*, Ji-Hye Yoon, Jane Jung, Yun-Hee Choi, Su-Man Kim, Hwa-Young Kim, Ji-Seon Ahn, Hangun Kim, Kwonseop Kim, Hyang-Sook Hoe and Hee-Sae Park

Journal of Cell Science, 124(11): 1831-1843 (2011) Jun (IF: 6.29)

 

8. Serum- and glucocorticoid-inducible Kinase1 (SGK1) controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.

Jung-Soon Mo, Eun-Jung Ann, Ji-Hye Yoon, Jane Jung, Yun-Hee Choi, Hwa-Young Kim, Ji-Seon Ahn, Su-Man Kim, Mi-Yeon Kim, Ji-Ae Hong, Mi-Sun Seo, Florian Lang, Eui-Ju Choi and Hee-Sae Park

Journal of Cell Science 124(1): 100-112 (2011) Jan (IF: 6.29)

 

7. Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation.

Eun-Jung Ann, Hwa-Young Kim, Yun-Hee Choi, Mi-Yeon Kim, Jung-Soon Mo, Su-Man Kim, Jane Jung, Ji-Hye Yoon, Jeong-Sik Moon, Mi-Sun Seo, Ji-Ae Hong, Won-Gu Jang, Paul Shore, Toshihisa Komori, Jeong-Tae Koh, and Hee-Sae Park

Journal of Bone and Mineral Research 26(2): 317-330 (2011) Feb (IF: 7.056)

 

6. JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway.

Mi-Yeon Kim*, Eun-Jung Ann*, Jung-Soon Mo*, Federico Dajas-Bailador, Mi-Sun Seo, Ji-Ae Hong, Jane Jung, Yun-Hee Choi, Ji-Hye Yoon, Su-Man Kim, Eui-Ju Choi, Hyang-Sook Hoe, Alan J. Whitmarsh and Hee-Sae Park

Cell Death and Differentiation 17(11): 1728-1738 (2010) Nov (IF: 9.05)

 

5. Down regulation of Notch signaling by lipopolysaccharide (LPS) through nitric oxide.

Mi-Yeon Kim*, Ji-Hye Park*, Jung-Soon Mo, Eun-Jung Ann, Seung-Ok Han, Sang-Hyun Baek, Kyoung-Jin Kim, Suhn-Young Im, Jeen-Woo Park, Eui-Ju Choi and Hee-Sae Park

Journal of Cell Science 121(Pt 9), 1466-1476 (2008) May 1 (IF: 6.29)

 

4. DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death.

Jung-Soon Mo, Mi-Yeon Kim, Eun-Jung Ann, Ji-Ae Hong and Hee-Sae Park

Cell Death and Differentiation 15(6), 1030-1041 (2008) June 1. (IF: 9.05)

 

3. Tip60 Histone Acetyltransferase Acts as a Negative Regulator of Notch1 Signaling by Means of Acetylation.

Mi-Yeon Kim, Eun-Jung Ann, Jin-Young Kim, Jung-Soon Mo, Ji-Hye Park, Sun-Yee Kim, Mi-Sun Seo, and Hee-Sae Park

Molecular and Cellular Biology. 27(18) 6506-6519 (2007) Sep 15. (IF: 6.773)

 

2. Integrin-Linked Kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.

Jung-Soon Mo*, Mi-Yeon Kim*, Seung-Ok Han, In-Sook Kim, Eun-Jung Ann, Kyu Shik Lee, Mi-Sun Seo, Jin-Young Kim, Seung-Chul Lee, Jeen-Woo Park, Eui-Ju Choi, Jae Young Seong, Cheol O, Joe, Reinhard Fäessler and Hee-Sae Park

Molecular and Cellular Biology. 27(15) 5565-5574 (2007) Aug 1. (IF: 6.773)

 

1.   Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction.

Sun-Yee Kim*, Mi-Yeon Kim*, Jung-Soon Mo and Hee-Sae Park

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1773(6):736-46 (2007) June 1. (IF: 6.9)